Article
TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics.
International journal of cancer - 1 Sept 2002
Simão Tatiana A, Ribeiro Fabiana S, Amorim Lídia M F, Albano Rodolpho M, Andrada-Serpa Maria J, Cardoso Lúis E B, Mendonça Gulnar A S, de Moura-Gallo Cláudia V
Abstract excerpt
Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 patients living in Rio de Janeiro, Brazil. TP53 mutations were found in 20% of the tumors, which...
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