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Article

TP53 mutations and SNPs as prognostic and predictive factors in patients with breast cancer (Review)

3 May 2018

Abstract excerpt

Tumor protein 53 (TP53) is a tumor suppressor gene that encodes tumor protein p53. Tumor protein p53 regulates the expression of target genes in response to cellular stress. Additionally, p53 participates in the regulation of cell cycle checkpoints, DNA repair and apoptosis. Mutations in the TP53 gene are associated with numerous types of human cancer, including breast cancer, sarcomas, brain tumors and adrenal...

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PMID: 29928384
DOI: 10.3892/ol.2018.8627

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