Article
Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA.
Thoracic cancer - 1 Jul 2020
Li Xuerui, Chen Xiaoqing, Wen Lingzhu, Wang Yulei, Chen Bo, Xue Yunlian, Guo Liping, Liao Ning
Abstract excerpt
BACKGROUND: TP53 is a crucial tumor suppressor gene. However, the mutation pattern of TP53 in Chinese patients with breast cancer has not yet been determined. METHODS: A total of 411 untreated patients with invasive breast cancer diagnosed at Guangdong Provincial People's Hospital (GDPH) between June 2017 to September 2018 were recruited into the study. Mutational alterations in TP53 were detected and...
Topics
- Biomarkers, Tumor
- Breast Neoplasms
- Cohort Studies
- DNA Mutational Analysis
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lymphatic Metastasis
- Middle Aged
- Mutation
- Neoplasm Invasiveness
- Prognosis
- Erb-b2 Receptor Tyrosine Kinases