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TP53 p.R337H prevalence in a series of Brazilian hereditary breast cancer families

13 Mar 2014

Abstract excerpt

BACKGROUND: Approximately 5-10% of breast cancers are hereditary. Among hereditary syndromes, Hereditary Breast and Ovarian Cancer Syndrome (HBOC) and Li-Fraumeni Syndrome (LFS) have received the most attention. HBOC is due to mutations in the BRCA1 and BRCA2 genes and is characterized by breast adenocarcinoma and/or epithelial ovarian carcinoma. LFS is associated with germline mutations in TP53; the most...

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PMID: 24625245
DOI: 10.1186/1897-4287-12-8

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