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Article

Etidronate influences growth and phenotype of rat vascular smooth muscle cells.

Pharmacological research - 1 Jul 2002

Su Jin-Zi, Fukuda Noboru, Kishioka Hirobumi, Hu Wen-Yang, Kanmatsuse Katsuo

Abstract excerpt

Bisphosphonates have been reported to exhibit antiarteriosclerotic and anticalcification effects. We investigated the effect of a bisphosphonate, etidronate, on growth and phenotype of vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR). Etidronate (10 microM) significantly decreased DNA synthesis evaluated by [3H]thymidine incorporation in VSMC cultured without serum, and 1 microM...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12208115
DOI: 10.1016/s1043-6618(02)00041-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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