Article
Vascular smooth muscle cell proliferation and its therapeutic modulation in hypertension.
American heart journal - 1 Oct 1991
Hadrava V, Kruppa U, Russo R C, Lacourcière Y, Tremblay J, Hamet P
Abstract excerpt
The increased growth potential of vascular smooth muscle cells (VSMCs) represents one of the crucial anomalies responsible for the development of essential hypertension, diabetic macroangiopathy, and atherosclerosis. The exaggerated response to growth factors of VSMC from spontaneously hypertensi...
Topics
- Animals
- Antihypertensive Agents
- Cell Division
- Cells, Cultured
- Gene Expression Regulation
- Growth Substances
- Humans
- Hypertension
- Muscle, Smooth, Vascular
- Phenotype
- Rats
- Rats, Inbred SHR
- Transforming Growth Factor beta