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Article

Arterial heparan sulfate proteoglycans inhibit vascular smooth muscle cell proliferation and phenotype change in vitro and neointimal formation in vivo.

Journal of vascular surgery - 1 Aug 1998

Bingley J A, Hayward I P, Campbell J H, Campbell G R

Abstract excerpt

PURPOSE: The aim of this study was to determine whether heparan sulfate proteoglycans (HSPGs) from the normal arterial wall inhibit neointimal formation after injury in vivo and smooth muscle cell (SMC) phenotype change and proliferation in vitro. METHODS: Arterial HSPGs were extracted from rabbit aortae and separated by anion-exchange chromatography. The effect of HSPGs, applied in a periadventitial gel, on...

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Identifiers

PMID: 9719326
DOI: 10.1016/s0741-5214(98)70167-3

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