Heparin-like glycosaminoglycans influence growth and phenotype of human arterial smooth muscle cells in vitro. I. Evidence for reversible binding and inactivation of the platelet-derived growth factor by heparin.

doi:10.1007/BF02631087

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Article

Heparin-like glycosaminoglycans influence growth and phenotype of human arterial smooth muscle cells in vitro. I. Evidence for reversible binding and inactivation of the platelet-derived growth factor by heparin.

In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 Mar 1992

Fager G, Camejo G, Bondjers G

Abstract excerpt

We have investigated the effects of interactions between growth factors and heparin-like glycosaminoglycans on untransformed human arterial smooth muscle cells (hASMC) in vitro. The results indicate that heparin in the presence of serum mitogens prevents the cells from entering the S phase of the cell cycle by binding and inactivating reversibly some serum mitogen(s). Our results suggest that platelet-derived...

Topics

Cell Division
Cells, Cultured
Chromatography, Affinity
Culture Media
DNA
Epidermal Growth Factor
Heparin
Humans
Insulin
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Phenotype

Platelet-Derived Growth Factor

Sepharose

Serotonin

Transferrin

Source

Open in PubMed

Identifiers

PMID: 1582991
DOI: 10.1007/BF02631087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1582991-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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