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Article

Differential effect of chronic antihypertensive treatment on vascular smooth muscle cell phenotype in spontaneously hypertensive rats.

Hypertension (Dallas, Tex. : 1979) - 1 May 2001

Bravo R, Somoza B, Ruiz-Gayo M, González C, Ruilope L M, Fernández-Alfonso M S

Abstract excerpt

The aim of this study was to investigate the effect of chronic losartan or captopril on vascular smooth muscle cell (VSMC) phenotype and vascular function in spontaneously hypertensive rats. Male 12-week-old rats were treated for 16 weeks with losartan (15 mg/kg per day) or captopril (60 mg/kg per day) in their drinking water. Systolic blood pressure, measured by the tail-cuff method, was reduced approximately 40...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endothelium, Vascular

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Share to Muscle, Smooth, Vascular

Share to Rats, Inbred SHR

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Source

Identifiers

PMID: 11358952
DOI: 10.1161/01.hyp.37.5.e4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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