Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype.

doi:10.1016/s0021-9150(98)00122-1

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Article

Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype.

Atherosclerosis - 1 Sept 1998

Song J, Wan Y, Rolfe B E, Campbell J H, Campbell G R

Abstract excerpt

To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E2) on phenotypic modulation and proliferation of rabbit aortic SMC were observed in vitro. At 10(-8)M, beta-E2 significantly slowed the decrease in volume fraction of myofilaments (Vv myo) of freshly dispersed SMCs in primary culture, indicating an inhibitory effect of beta-E2 on...

Topics

Animals
Cell Cycle
Cell Division
DNA Replication
Estradiol
Female
Muscle Contraction
Muscle, Smooth, Vascular
Phenotype
Rabbits
Thymidine

Source

Open in PubMed

Identifiers

PMID: 9733220
DOI: 10.1016/s0021-9150(98)00122-1

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