Article
The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.
Yonsei medical journal - 1 Aug 2002
Kim Jung-Sun, Park Hyun-Young, Kwon Jun Hye, Im Eun Kyung, Choi Dong Hoon, Jang Yang Soo, Cho Seung-Yun
Abstract excerpt
Matrix metalloproteinases contribute to vascular remodeling by breaking down extracellular-matrix while new matrix is synthesized. Of the variety of MMPs, stromelysin-1 and gelatinase B may have key roles in coronary artery atherosclerosis. Moreover, The 5A/6A polymorphism in the promoter region of the stromelysin-1 gene may be a pathogenetic risk factor for acute myocardial infarction. Gelatinase B (92-kDa type...
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