Analysis of Matrix Metalloproteinase-8 Gene Polymorphisms and Their Association with Long-Term Survival, Clinical Phenotype, and Disease Risk in Patients with Coronary Artery Disease.

Abstract excerpt

Matrix metalloproteinase-8 (MMP-8), a neutrophil-derived collagenase responsible for the degradation of type I and III collagen, is involved in extracellular matrix remodeling, which may contribute to the destabilization of atherosclerotic plaques and thereby promote the development and progression of coronary artery disease (CAD). Single-nucleotide polymorphisms (SNPs) in the MMP-8 gene may influence the...

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