Article
Genetic variation in human stromelysin gene promoter and common carotid geometry in healthy male subjects.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2000
Gnasso A, Motti C, Irace C, Carallo C, Liberatoscioli L, Bernardini S, Massoud R, Mattioli P L, Federici G, Cortese C
Abstract excerpt
A common variant in the promoter of the human stromelysin gene, causing reduced enzyme expression, has been associated with the progression of coronary atherosclerosis. On the other hand, increased stromelysin activity may promote plaque rupture. The present study was undertaken to investigate the relationship between the genetic variation in the human stromelysin gene promoter and common carotid geometry....
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