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Article

The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis.

European heart journal - 1 May 2002

Humphries S, Bauters C, Meirhaeghe A, Luong L, Bertrand M, Amouyel P

Abstract excerpt

AIMS: Intracoronary ultrasound studies in humans show that chronic remodelling rather than neointimal hyperplasia is the mechanism of restenosis. Stent implantation limits this remodelling process and significantly reduces restenosis. MMP3 (Stromelysin-1), a member of the matrix metalloproteinase family may play a role in this remodelling. We used a functional polymorphism (with alleles designated 5A or 6A) in...

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Source

Identifiers

PMID: 11977998
DOI: 10.1053/euhj.2001.2895

Genes

MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis.PMID 11977998Read ↗

5A/6A polymorphism of the stromelysin-1 gene and angiographic restenosis after coronary artery stenting.Semantic proximity Read ↗

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The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis.Semantic proximity Read ↗

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Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis.Semantic proximity Read ↗

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