Article
Synergistic effect of stromelysin-1 (matrix metallo-proteinase-3) promoter 5A/6A polymorphism with smoking on the onset of young acute myocardial infarction.
Thrombosis and haemostasis - 1 Jul 2003
Liu Ping-Yen, Chen Jyh-Hong, Li Yi-Heng, Wu Hua-Lin, Shi Guey-Yueh
Abstract excerpt
The objective of this study was to elucidate the association between the polymorphism of stromelysin-1, also called matrix metalloproteinases-3 (MMP-3), and smoking in the pathogenesis of young acute myocardial infarction (MI). Plaque rupture is well established as a critical factor in the pathogenesis of acute MI. MMP-3 can degrade extracellular matrix and are identified extensively in human coronary...
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