Article

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

2020-10-09

Abstract excerpt

<h4>ABSTRACT</h4> After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from the slow growth of axons. This impairs axonal regeneration and causes a significant clinical problem. In mice, we find that repair cells express reduced c-...

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Literature Corpus work: d006ad1a-f52b-5a8b-83a5-d3d901e9a65f
DOI: 10.1101/2020.10.06.327957

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