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Article

Mechanism of increased open probability by a mutation of the BK channel.

Journal of neurophysiology - 1 Sept 2006

Díez-Sampedro Ana, Silverman William R, Bautista Jocelyn F, Richerson George B

Abstract excerpt

A missense mutation (D434G) has recently been identified in the alpha subunit of the human large-conductance calcium-activated potassium (BK) channel. Interestingly, although the mutation causes an increase in open probability, individuals that carry the mutation have epilepsy and/or paroxysmal dyskinesia, disorders of increased brain excitability. To define the mechanisms of the mutation, we have used recordings...

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Identifiers

PMID: 16738211
DOI: 10.1152/jn.00461.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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