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Article

Pharmacogenomics and Morphine.

Journal of clinical pharmacology - 1 Sept 2021

Ofoegbu Adaku, B Ettienne Earl

Abstract excerpt

Morphine is an opioid analgesic indicated in the treatment of acute and chronic moderate to severe pain. From a pharmacodynamic standpoint, morphine exerts its effects by agonizing mu-opioid receptors predominantly, resulting in analgesia and sedation. Pharmacokinetically, morphine is primarily metabolized in the liver via glucuronidation by the enzyme uridine diphosphate glucuronosyltransferase family 2 member...

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Source

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Identifiers

PMID: 33847389
DOI: 10.1002/jcph.1873
PMCID: PMC8453761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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