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Article

Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene.

Pharmacogenetics and genomics - 1 Aug 2008

Innocenti Federico, Liu Wanqing, Fackenthal Donna, Ramírez Jacqueline, Chen Peixian, Ye Xin, Wu Xiaolin, Zhang Wei, Mirkov Snezana, Das Soma, Cook Edwin, Ratain Mark J

Abstract excerpt

OBJECTIVE: UDP-glucuronosyltransferase 2B7 (UGT2B7) plays a central role in the liver-mediated biotransformation of endogenous and exogenous compounds. The genetic basis of interindividual variability in UGT2B7 function is unknown. This study aimed to discover novel gene variants of functional significance. METHODS: Caucasian human livers (n=54) were used. UGT2B7 was resequenced in 12 samples [(six highest and...

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Identifiers

PMID: 18622261
DOI: 10.1097/FPC.0b013e3283037fe4
PMCID: PMC2680356

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