Article
Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 2003
Hirota Takeshi, Ieiri Ichiro, Takane Hiroshi, Sano Hiroyuki, Kawamoto Katsuyuki, Aono Hironao, Yamasaki Akira, Takeuchi Hiromi, Masada Mikio, Shimizu Eiji, Higuchi Shun, Otsubo Kenji
Abstract excerpt
In this case report, we present genetic differences in two morphine-related gene sequences, UDP-glucuronosyltransferase 2B7 (UGT2B7) and mu opioid receptors (MOR1), in two cancer patients whose clinical responses to morphine were very different [i.e., sensitive (patient 1) and low responder (patient 2)]. In addition, allelic variants in the UGT2B7 gene were analyzed in 46 Japanese individuals. Amplified DNA...
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