Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer.

Cancer chemotherapy and pharmacology - 1 Jan 2010

Fujita Ken-ichi, Ando Yuichi, Yamamoto Wataru, Miya Toshimichi, Endo Hisashi, Sunakawa Yu, Araki Kazuhiro, Kodama Keiji, Nagashima Fumio, Ichikawa Wataru, Narabayashi Masaru, Akiyama Yuko, Kawara Kaori, Shiomi Mari, Ogata Hiroyasu, Iwasa Hiroyasu, Okazaki Yasushi, Hirose Takashi, Sasaki Yasutsuna

Abstract excerpt

PURPOSE: To investigate the effects of genetic polymorphisms on morphine-induced adverse events in cancer patients. METHODS: We examined the relation of morphine-related adverse events to polymorphisms in UDP-glucuronosyltransferase (UGT) 2B7, ATP-binding cassette, sub-family B, number 1 (ABCB1), and μ-opioid receptor 1 genes in 32 Japanese cancer patients receiving oral controlled-release morphine sulfate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Delayed-Action Preparations

Share to Glucuronosyltransferase

Share to Morphine

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 19466410
DOI: 10.1007/s00280-009-1029-2

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer.PMID 19466410Read ↗

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy.Semantic proximity Read ↗

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.Semantic proximity Read ↗

Study on the association between adverse drug reactions to opioids and gene polymorphisms: a case-case-control study.Semantic proximity Read ↗

Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain.Semantic proximity Read ↗

A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine.Semantic proximity Read ↗

Association of Allelic Interaction of Single Nucleotide Polymorphisms of Influx and Efflux Transporters Genes With Nonhematologic Adverse Events of Docetaxel in Breast Cancer Patients.Semantic proximity Read ↗

The impact of UGT2B7 C802T and CYP3A4*1G polymorphisms on pain relief in cancer patients receiving oxycontin.Semantic proximity Read ↗

Environmental and genetic factors associated with morphine response in the postoperative period.Semantic proximity Read ↗

[Effect of opioid-related gene polymorphisms on patients with high-dose opioid-tolerant cancer pain].Semantic proximity Read ↗

Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy.Semantic proximity Read ↗

Association of the OPRM1 variant rs1799971 (A118G) and clinical manifestations in tramadol poisoned patients: a cross-sectional study.Semantic proximity Read ↗

Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.