Article
A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine.
Clinical pharmacology and therapeutics - 1 Jun 2003
Sawyer Michael B, Innocenti Federico, Das Soma, Cheng Cheng, Ramírez Jacqueline, Pantle-Fisher Friedl H, Wright Constance, Badner Judith, Pei Deqing, Boyett James M, Cook Edwin, Ratain Mark J
Abstract excerpt
We investigated the variation in the uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) gene in patients receiving patient-controlled analgesia with morphine. UGT2B7 was sequenced in phenotypic extremes (n = 12) of the distribution of morphine-6-glucuronide/morphine plasma ratios. A new -16...
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