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Article

Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain.

Pharmacogenetics and genomics - 1 Mar 2013

Fladvad Torill, Klepstad Pål, Langaas Mette, Dale Ola, Kaasa Stein, Caraceni Augusto, Skorpen Frank

Abstract excerpt

OBJECTIVE: The objective of the present study was to determine whether genetic variability in UDP-glucuronosyltransferase (UGT) genes, together with clinical factors, contribute to variability in morphine glucuronide (M6G and M3G) to morphine serum concentration ratios in patients with advanced cancer receiving chronic morphine therapy. MATERIALS AND METHODS: A total of 41 polymorphisms and predicted haplotypes...

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PMID: 23277092
DOI: 10.1097/FPC.0b013e32835ce485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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