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Article

A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.

PLoS genetics - 1 Jan 2012

Sansó Miriam, Lee Karen M, Viladevall Laia, Jacques Pierre-Étienne, Pagé Viviane, Nagy Stephen, Racine Ariane, St Amour Courtney V, Zhang Chao, Shokat Kevan M, Schwer Beate, Robert François, Fisher Robert P, Tanny Jason C

Abstract excerpt

Transcript elongation by RNA polymerase II (RNAPII) is accompanied by conserved patterns of histone modification. Whereas histone modifications have established roles in transcription initiation, their functions during elongation are not understood. Mono-ubiquitylation of histone H2B (H2Bub1) plays a key role in coordinating co-transcriptional histone modification by promoting site-specific methylation of histone...

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Identifiers

PMID: 22876190
DOI: 10.1371/journal.pgen.1002822
PMCID: PMC3410854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.PMID 22876190Read ↗

Histone H2B Monoubiquitylation Regulates Elongation-to-Termination Transition in RNA Polymerase II TranscriptionSemantic proximity Read ↗

Histone H2B Monoubiquitylation Regulates Elongation-to-Termination Transition in RNA Polymerase II TranscriptionSemantic proximity Read ↗

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Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase IISemantic proximity Read ↗

Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II.Semantic proximity Read ↗

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Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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