Article
TBP-like factor is required for embryonic RNA polymerase II transcription in C. elegans.
Molecular cell - 1 Sept 2000
Dantonel J C, Quintin S, Lakatos L, Labouesse M, Tora L
Abstract excerpt
Recently, a novel family of TATA binding protein (TBP)-like factors (TLFs) have been described in metazoan organisms; however, their function has not yet been elucidated. Using Caenorhabditis elegans (Ce) as a model, we demonstrate that CeTLF is required in vivo for zygotic transcription during embryogenesis. Elimination of CeTLF expression by RNA interference caused embryonic lethality either due to the lack of...
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