Article
P-TEFb, the super elongation complex and mediator regulate a subset of non-paused genes during early Drosophila embryo development.
PLoS genetics - 1 Feb 2015
Dahlberg Olle, Shilkova Olga, Tang Min, Holmqvist Per-Henrik, Mannervik Mattias
Abstract excerpt
Positive Transcription Elongation Factor b (P-TEFb) is a kinase consisting of Cdk9 and Cyclin T that releases RNA Polymerase II (Pol II) into active elongation. It can assemble into a larger Super Elongation Complex (SEC) consisting of additional elongation factors. Here, we use a miRNA-based approach to knock down the maternal contribution of P-TEFb and SEC components in early Drosophila embryos. P-TEFb or SEC...
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