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Article

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.

Molecular pharmacology - 1 Sept 2002

Ferguson Stephen S, LeCluyse Edward L, Negishi Masahiko, Goldstein Joyce A

Abstract excerpt

The CYP2C subfamily metabolizes many clinically important drugs. These genes respond to prototypical inducers such as phenobarbital and rifampicin, yet little has been reported on the mechanisms of induction. This report examines the regulation of CYP2C9 with respect to two specific receptors thought to be involved in phenobarbital (PB) induction, the constitutive androstane receptor (CAR) and pregnane X receptor...

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Source

Identifiers

PMID: 12181452
DOI: 10.1124/mol.62.3.737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.PMID 12181452Read ↗

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The Transcriptional Regulation of the Human CYP2C GenesSemantic proximity Read ↗

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