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Article

Transcriptional Regulation of Cytochrome P450 2B Genes by Nuclear Receptors

1 Dec 2003

Abstract excerpt

Cytochrome p450 2B genes have been used extensively as prototypical models to study phenobarbital induction of p450 enzymes. Although its basal hepatic abundance is relatively low, CYP2B is highly inducible by various chemicals. Cross regulation and shared substrate specificity of CYP2B with CYP3A and other drug metabolizing enzymes lend support to the pharmacological and toxicological significance of CYP2B...

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PMID: 14683479
DOI: 10.2174/1389200033489262

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