Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by Phenytoin

1 Jul 2004

Abstract excerpt

Compared with its rodent orthologs, little is known about the chemical specificity of human constitutive androstane receptor (hCAR) and its regulation of hepatic enzyme expression. Phenytoin (PHY), a widely used antiepileptic drug, is a potent inducer of CYP2B6 in primary human hepatocytes, but does not activate human pregnane X receptor (PXR) significantly in cell-based transfection assays at the same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Pharmacogenetics and Drug Metabolism
Share to Pharmacological Effects and Toxicity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15123723
DOI: 10.1074/jbc.m400580200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by PhenytoinPMID 15123723Read ↗

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.Semantic proximity Read ↗

Transcriptional Regulation of Cytochrome P450 2B Genes by Nuclear ReceptorsSemantic proximity Read ↗

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Semantic proximity Read ↗

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.Semantic proximity Read ↗

Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X ReceptorsSemantic proximity Read ↗

Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)Semantic proximity Read ↗

The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X ReceptorSemantic proximity Read ↗

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cellsSemantic proximity Read ↗

Orphan Nuclear Receptors: The Exotics of XenobioticsSemantic proximity Read ↗

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)Semantic proximity Read ↗

Transcriptional Analysis of the Orphan Nuclear Receptor Constitutive Androstane Receptor (NR1I3) Gene Promoter: Identification of a Distal Glucocorticoid Response ElementSemantic proximity Read ↗

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.