Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.

Archives of biochemistry and biophysics - 15 Jul 2006

Zhang Quanyuan, Bae Yangjin, Kemper Jongsook Kim, Kemper Byron

Abstract excerpt

The phenobarbital (PB) responsive enhancers in CYP2B genes contain a core of two direct repeat-4 nuclear receptor binding sites, NR-1 and NR-2, which flank an NF-1 site and appear to be most important for PB responsiveness. Additional sequences outside the core are required for maximal PB responsiveness, including a third direct repeat-4 site, NR-3. The PB response is mediated by constitutive androstane receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Constitutive Androstane Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dimerization

Share to Hepatocytes

Share to Nucleosomes

Share to Phenobarbital

Share to Receptors, Cytoplasmic and Nuclear

Share to Retinoid X Receptors

Source

Identifiers

PMID: 16725103
DOI: 10.1016/j.abb.2006.04.016

Genes

SRC
GRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.PMID 16725103Read ↗

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.Semantic proximity Read ↗

Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PBRU.Semantic proximity Read ↗

Transcriptional Analysis of the Orphan Nuclear Receptor Constitutive Androstane Receptor (NR1I3) Gene Promoter: Identification of a Distal Glucocorticoid Response ElementSemantic proximity Read ↗

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.Semantic proximity Read ↗

Identification and functional analysis of a novel human CYP2E1 far upstream enhancer.Semantic proximity Read ↗

Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation.Semantic proximity Read ↗

Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.Semantic proximity Read ↗

Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytesSemantic proximity Read ↗

Subcellular trafficking signals of constitutive androstane receptor: evidence for a nuclear export signal in the DNA-binding domain.Semantic proximity Read ↗

Nuclear receptor-mediated regulation of carboxylesterase expression and activitySemantic proximity Read ↗

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).Semantic proximity Read ↗

Functional analysis of four naturally occurring variants of human constitutive androstane receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.