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Article

Transcriptional Regulation of CYP2C9 Gene

1 Jan 2002

Abstract excerpt

Although cytochrome P450 2C9 (CYP2C9) is a major CYP expressed in the adult human liver, its mechanism of regulation is poorly known. In previous work, we have shown that CYP2C9 is inducible in primary human hepatocytes by xenobiotics including dexamethasone, rifampicin, and phenobarbital. The aim of this work was to investigate the molecular mechanism(s) controlling the inducible expression of CYP2C9. Deletional...

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PMID: 11679585
DOI: 10.1074/jbc.m107228200

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