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Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes

7 Jan 2009

Abstract excerpt

Chromatin immunoprecipitation (ChIP) studies were conducted in human hepatocytes treated with rifampicin in order to identify new pregnane-X receptor (PXR) target genes. Genes, both previously known to be involved and not known to be involved in drug disposition, with PXR response elements (PXREs) located upstream, within or downstream from their potentially associated genes, were identified. Validation...

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PMID: 19129222
DOI: 10.1093/nar/gkn1047

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