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Article

A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation

23 Jun 2003

Abstract excerpt

Activating mutations in FGF receptor 3 (FGFR3) cause several human dwarfism syndromes by affecting both chondrocyte proliferation and differentiation. Using microarray and biochemical analyses of FGF-treated rat chondrosarcoma chondrocytes, we show that FGF inhibits chondrocyte proliferation by initiating multiple pathways that result in the induction of antiproliferative functions and the down-regulation of...

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PMID: 12821644
DOI: 10.1083/jcb.200302075

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