FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells.

doi:10.1016/j.yexcr.2004.03.011

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Article

FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells.

Experimental cell research - 1 Jul 2004

Krejci Pavel, Bryja Vitezslav, Pachernik Jiri, Hampl Ales, Pogue Robert, Mekikian Pertchoui, Wilcox William R

Abstract excerpt

Several forms of human dwarfism are due to activating mutations in FGFR3 highlighting the role of FGF signaling in the growth attenuation of cartilage. Here, we studied the effects of FGF2 on RCS chondrocytes. Treatment with FGF2 induced growth arrest in the G1 phase of the cell cycle and partial de-differentiation of cells manifested by changes in cell morphology, loss of the cartilage-like extracellular matrix,...

Topics

Animals
Cartilage
Cell Cycle Proteins
Cell Differentiation
Cell Division
Cell Line
Chondrocytes
Cyclin-Dependent Kinases
Cyclins
Enzyme Inhibitors
Fibroblast Growth Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Dominant

Macromolecular Substances

Mice

Mitogen-Activated Protein Kinase Kinases

Phenotype

Protein-Tyrosine Kinases

Rats

Source

Open in PubMed

Identifiers

PMID: 15194433
DOI: 10.1016/j.yexcr.2004.03.011

Genes

FGF2
FGFR3

Provenance

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