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Article

Negative Regulation of DNA Replication by the Retinoblastoma Protein Is Mediated by Its Association with MCM7

1 May 1998

Abstract excerpt

A yeast two-hybrid screen was employed to identify human proteins that specifically bind the amino-terminal 400 amino acids of the retinoblastoma (Rb) protein. Two independent cDNAs resulting from this screen were found to encode the carboxy-terminal 137 amino acids of MCM7, a member of a family of proteins that comprise replication licensing factor. Full-length Rb and MCM7 form protein complexes in vitro, and...

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Identifiers

PMID: 9566894
DOI: 10.1128/mcb.18.5.2748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Negative Regulation of DNA Replication by the Retinoblastoma Protein Is Mediated by Its Association with MCM7PMID 9566894Read ↗

Regulation of the retinoblastoma proteins by the human herpesvirusesSemantic proximity Read ↗

The DNA replication licensing factor miniature chromosome maintenance 7 is essential for RNA splicing of epidermal growth factor receptor, c-Met, and platelet-derived growth factor receptor.Semantic proximity Read ↗

The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.Semantic proximity Read ↗

The amino terminus of the retinoblastoma (Rb) protein associates with a cyclin-dependent kinase-like kinase via Rb amino acids required for growth suppression.Semantic proximity Read ↗

The RLF‐M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptidesSemantic proximity Read ↗

FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest.Semantic proximity Read ↗

Human Cytomegalovirus pp71 Stimulates Cell Cycle Progression by Inducing the Proteasome-Dependent Degradation of the Retinoblastoma Family of Tumor SuppressorsSemantic proximity Read ↗

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.Semantic proximity Read ↗

A common set of nuclear factors bind to promoter elements regulated by the retinoblastoma protein.Semantic proximity Read ↗

Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirusSemantic proximity Read ↗

Inhibition of DNA binding of MCM2-7 complex by phosphorylation with cyclin-dependent kinases.Semantic proximity Read ↗

Nuclear binding of purified retinoblastoma gene product is determined by cell cycle-regulated phosphorylation.Semantic proximity Read ↗

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