Article
Integrating sibship data for mapping quantitative trait loci.
Annals of human genetics - 1 Mar 2002
Ghosh S, Reich T
Abstract excerpt
Sibship methods have been shown to be more powerful than traditional sib-pair methods in mapping quantative trait loci. We propose a statistical procedure which integrates data on sibships into a so-called 'contrast function', a natural extension of the classical squared sib-pair trait difference proposed by Haseman & Elston (1972). We also develop a combined mean and contrast function which provides more...
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