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Article

Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling.

Blood - 1 Jul 2006

Campese Antonio F, Garbe Annette I, Zhang Fangrong, Grassi Fabio, Screpanti Isabella, von Boehmer Harald

Abstract excerpt

Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia-Lymphoma, Adult T-Cell

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Source

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Identifiers

PMID: 16507772
DOI: 10.1182/blood-2006-01-0143
PMCID: PMC1895839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling.PMID 16507772Read ↗

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