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Article

Concurrent LOH at multiple loci in human malignant mesothelioma with preferential loss of NF2 gene region.

Oncology reports - 1 Jan 2000

Pylkkänen Lea, Sainio Markku, Ollikainen Tiina, Mattson Karin, Nordling Stig, Carpén Olli, Linnainmaa Kaija, Husgafvel-Pursiainen Kirsti

Abstract excerpt

Human malignant mesothelioma (MM) is a highly aggressive neoplasm related to occupational asbestos exposure and characterised by a long latency period between the exposure and onset of disease. Previous studies indicate that losses at different genomic regions are present in MM. We examined allele loss at three known tumour suppressor gene regions (22q/NF2 gene, 9p/p16 gene, and 3p/FHIT gene) and at two other...

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Identifiers

PMID: 12168054

Genes

FHIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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