Article
Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of the NF2 gene.
International journal of cancer - 12 Aug 1998
Deguen B, Goutebroze L, Giovannini M, Boisson C, van der Neut R, Jaurand M C, Thomas G
Abstract excerpt
Germ-line mutations in the neurofibromatosis 2 (NF2) gene cause a susceptibility to the development of schwannoma and meningioma, 2 mostly benign tumors of neural crest origin. Bi-allelic inactivation of this gene has been observed in sporadic schwannomas and meningiomas. The NF2 gene may also be...
Topics
- Alleles
- Electrophoresis
- Genes, Tumor Suppressor
- HeLa Cells
- Humans
- Loss of Heterozygosity
- Membrane Proteins
- Mesothelioma
- Neoplasm Proteins
- Neurofibromin 2
- Polymerase Chain Reaction
- RNA, Messenger
- Sequence Analysis, DNA
- Tumor Cells, Cultured