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Article

Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: evidence for a two-hit mechanism of NF2 inactivation.

Genes, chromosomes & cancer - 1 Mar 1999

Cheng J Q, Lee W C, Klein M A, Cheng G Z, Jhanwar S C, Testa J R

Abstract excerpt

We previously reported NF2 mutations in malignant mesothelioma (MM) cell lines and corresponding primary tumors. We have now generated polyclonal antibodies that specifically recognize the C-terminus of the NF2 protein. Western blot analysis was performed on 25 MM cell lines, 14 of which showed no NF2 expression. Single-strand conformation polymorphism and DNA sequence analyses revealed NF2 mutations in each of...

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Share to Chromosomes, Human, Pair 22
Share to Genes, Neurofibromatosis 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Mesothelioma

Share to Neoplasm Proteins

Share to Neurofibromin 2

Share to Polymorphism, Single-Stranded Conformational

Share to Tumor Cells, Cultured

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PMID: 10451704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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