Article
Mutational analysis of the nf2 tumour suppressor gene in three subtypes of primary human malignant mesotheliomas.
International journal of oncology - 1 May 2003
Schipper Holger, Papp Thilo, Johnen Georg, Pemsel Heidi, Bastrop Ralf, Müller Klaus-Michael, Wiethege Thorsten, Jaworska Malgorzata, Krismann Michael, Schiffmann Dietmar, Rahman Qamar
Abstract excerpt
Fourteen primary human malignant mesothelioma (HMM) samples obtained from 14 patients were screened for point mutations and microdeletions/microinsertions in exons 1-16 of the chromosome 22q-located tumour suppressor gene neurofibromin 2 (nf2) by single strand conformation polymorphism (SSCP) analysis. In one tumour (7%) a 10 basepair microdeletion of exon 10 was detected by SSCP and subsequently characterised in...
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