Article
Similar tumor suppressor gene alteration profiles in asbestos-induced murine and human mesothelioma.
Cell cycle (Georgetown, Tex.) - 1 Dec 2005
Lecomte Céline, Andujar Pascal, Renier Annie, Kheuang Laurence, Abramowski Vincent, Mellottee Lucille, Fleury-Feith Jocelyne, Zucman-Rossi Jessica, Giovannini Marco, Jaurand Marie-Claude
Abstract excerpt
Human malignant mesothelioma (HMM) is an aggressive malignancy mainly caused by exposure to asbestos fibers. Here we investigated tumor suppressor genes in mesothelioma cells from tumoral ascites developed in mice exposed to asbestos (asb) fibers and in 12 HMM cell cultures. Mutations in Nf2, p16/Cdkn2a, p19/Arf and Trp53 genes and protein expression of p15/Cdkn2b and Cdk4 were analyzed in 12 cultures from mice...
Topics
- Animals
- Asbestos
- DNA Mutational Analysis
- Gene Expression Profiling
- Genes, Tumor Suppressor
- Humans
- Mesothelioma
- Mice
- Mice, Knockout
- Mutation
- Tumor Cells, Cultured
- Tumor Suppressor Proteins