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Article

Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity.

Molecular and cellular biology - 1 Sept 2002

Ocampo Maria T A, Chaung Wenren, Marenstein Dina R, Chan Michael K, Altamirano Alvin, Basu Ashis K, Boorstein Robert J, Cunningham Richard P, Teebor George W

Abstract excerpt

DNA N-glycosylase/AP (apurinic/apyrimidinic) lyase enzymes of the endonuclease III family (nth in Escherichia coli and Nth1 in mammalian organisms) initiate DNA base excision repair of oxidized ring saturated pyrimidine residues. We generated a null mouse (mNth1(-/-)) by gene targeting. After almost 2 years, such mice exhibited no overt abnormalities. Tissues of mNth1(-/-) mice contained an enzymatic activity...

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Identifiers

PMID: 12167705
DOI: 10.1128/MCB.22.17.6111-6121.2002
PMCID: PMC134015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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