Article
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
DNA repair - 4 Jul 2009
Chan Michael K, Ocampo-Hafalla Maria T, Vartanian Vladimir, Jaruga Pawel, Kirkali Güldal, Koenig Karen L, Brown Stuart, Lloyd R Stephen, Dizdaroglu Miral, Teebor George W
Abstract excerpt
We have generated a strain of mice lacking two DNA N-glycosylases of base excision repair (BER), NTH1 and NEIL1, homologs of bacterial Nth (endonuclease three) and Nei (endonuclease eight). Although these enzymes remove several oxidized bases from DNA, they do not remove the well-known carcinogenic oxidation product of guanine: 7,8-dihydro-8-oxoguanine (8-OH-Gua), which is removed by another DNA N-glycosylase,...
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