Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.

doi:10.1093/emboj/cdf350

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Article

Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.

The EMBO journal - 1 Jul 2002

Takao Masashi, Kanno Shin-ichiro, Shiromoto Tatsuya, Hasegawa Rei, Ide Hiroshi, Ikeda Shogo, Sarker Altaf H, Seki Shuji, Xing James Z, Le X Chris, Weinfeld Michael, Kobayashi Kumiko, Miyazaki Jun-ichi, Muijtjens Manja, Hoeijmakers Jan H J, van der Horst Gijsbertus, Yasui Akira, Sarker Altraf H

Abstract excerpt

Endonuclease III, encoded by nth in Escherichia coli, removes thymine glycols (Tg), a toxic oxidative DNA lesion. To determine the biological significance of this repair in mammals, we established a mouse model with mutated mNth1, a homolog of nth, by gene targeting. The homozygous mNth1 mutant mice showed no detectable phenotypical abnormality. Embryonic cells with or without wild-type mNth1 showed no difference...

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PMID: 12093749
DOI: 10.1093/emboj/cdf350
PMCID: PMC125395

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