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Article

Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.

The Journal of biological chemistry - 27 Dec 2002

Elder Rhoderick H, Dianov Grigory L

Abstract excerpt

In mammalian cells, thymine glycols and other oxidized pyrimidines such as 5,6-dihydrouracil are removed from DNA by the NTH1 protein, a bifunctional DNA-N-glycosylase. However, mNTH1 knock-out mice in common with other DNA glycosylase-deficient mice do not show any severe abnormalities associated with accumulation of DNA damage and mutations. In the present study we used an in vitro repair system to investigate...

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Identifiers

PMID: 12401779
DOI: 10.1074/jbc.M208153200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.PMID 12401779Read ↗

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