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Article

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

Nature - 17 Feb 2011

Cortázar Daniel, Kunz Christophe, Selfridge Jim, Lettieri Teresa, Saito Yusuke, MacDougall Eilidh, Wirz Annika, Schuermann David, Jacobs Angelika L, Siegrist Fredy, Steinacher Roland, Jiricny Josef, Bird Adrian, Schär Primo

Abstract excerpt

Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG) superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired with guanine, it was proposed to act against the mutability of 5-methylcytosine (5-mC) deamination in mammalian DNA. However, TDG was also found to interact with transcription factors, histone acetyltransferases and de novo DNA methyltransferases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21278727
DOI: 10.1038/nature09672

Genes

TDG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.PMID 21278727Read ↗

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