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Article

The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.

DNA repair - 13 May 2003

Rosenquist Thomas A, Zaika Elena, Fernandes Andrea S, Zharkov Dmitry O, Miller Holly, Grollman Arthur P

Abstract excerpt

DNA damage mediated by reactive oxygen species generates miscoding and blocking lesions that may lead to mutations or cell death. Base excision repair (BER) constitutes a universal mechanism for removing oxidatively damaged bases and restoring the integrity of genomic DNA. In Escherichia coli, the DNA glycosylases Nei, Fpg, and Nth initiate BER of oxidative lesions; OGG1 and NTH1 proteins fulfill a similar...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12713815
DOI: 10.1016/s1568-7864(03)00025-9

Genes

NEIL1
NEIL2
NEIL3
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.PMID 12713815Read ↗

Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme.Semantic proximity Read ↗

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.Semantic proximity Read ↗

Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.Semantic proximity Read ↗

DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.Semantic proximity Read ↗

NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.Semantic proximity Read ↗

NTHL1 in genomic integrity, aging and cancer.Semantic proximity Read ↗

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.Semantic proximity Read ↗

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.Semantic proximity Read ↗

Coordination of DNA repair by NEIL1 and PARP-1: a possible link to agingSemantic proximity Read ↗

New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Semantic proximity Read ↗

Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.Semantic proximity Read ↗

Functional roles and cancer variants of the bifunctional glycosylase NEIL2Semantic proximity Read ↗

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