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Article

Functional cooperation of Ogg1 and Mutyh in preventing G: C-->T: a transversions in mice.

Fukuoka igaku zasshi = Hukuoka acta medica - 1 Jan 2004

Isogawa Asako

Abstract excerpt

Oxygen radicals generated through normal cellular metabolism induce a variety of types of oxidative damage into DNA and its precursors. Among such types of oxidative damage, 7, 8-dihydro-8-oxoguanine (8-oxoG), an oxidized form of guanine, is known to be abundant and highly mutagenic. 8-OxoG can pair with adenine as well as cytosine, thus causing G: C to T: A transversions after DNA replication, if not repaired....

Topics

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DNA Damage
DNA Glycosylases
DNA Replication
Frameshift Mutation
Guanosine
Intestine, Small

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidative Stress

Source

Identifiers

PMID: 15031996

Genes

MUTYH
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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