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Article

Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2016

Hurt Darrell E, Suzuki Shigeru, Mayama Takafumi, Charmandari Evangelia, Kino Tomoshige

Abstract excerpt

Glucocorticoid receptor (GR) gene mutations may cause familial or sporadic generalized glucocorticoid resistance syndrome. Most of the missense forms distribute in the ligand-binding domain and impair its ligand-binding activity and formation of the activation function (AF)-2 that binds LXXLL motif-containing coactivators. We performed molecular dynamics simulations to ligand-binding domain of pathologic GR...

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Identifiers

PMID: 26745667
DOI: 10.1210/me.2015-1177
PMCID: PMC4792232

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LBP

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